Activation | Inactivation | Kinetics at −20 mV | |||||||
---|---|---|---|---|---|---|---|---|---|
V50(mV) | k (mV) | n | V50(mV) | k (mV) | n | τact(ms) | τinact(ms) | n | |
WT | −43.8 ± 0.8 | 6.3 ± 0.1 | 12 | −78.1 ± 1.2 | −5.7 ± 0.1 | 7 | 2.9 ± 0.1 | 17.4 ± 0.9 | 12 |
D1 | −64.7 ± 0.8*** | 5.2 ± 0.1** | 22 | −90.0 ± 0.8*** | −4.4 ± 0.1*** | 8 | 2.2 ± 0.2** | 27.8 ± 2.5*** | 15 |
D2 | −60.4 ± 1.0*** | 5.4 ± 0.2* | 22 | −88.2 ± 0.8*** | −4.5 ± 0.2* | 5 | 1.7 ± 0.1*** | 18.3 ± 0.6 | 18 |
D3 | −45.3 ± 0.6 | 6.1 ± 0.3 | 15 | −78.8 ± 1.4 | −5.1 ± 0.2 | 7 | 3.0 ± 0.1 | 15.8 ± 0.8 | 13 |
D1–D3 | −63.8 ± 1.4*** | 4.6 ± 0.2*** | 16 | −92.0 ± 0.9*** | −3.8 ± 0.1*** | 9 | 1.5 ± 0.1*** | 14.0 ± 0.8 | 14 |
D4 | −47.0 ± 0.9 | 6.1 ± 0.1 | 16 | −78.8 ± 1.4 | −4.9 ± 0.1 | 6 | 3.1 ± 0.1 | 15.7 ± 0.6 | 15 |
D5 | −47.2 ± 0.6 | 6.0 ± 0.2 | 16 | −79.7 ± 1.0 | −5.3 ± 0.2 | 9 | 2.8 ± 0.2 | 16.0 ± 0.4 | 13 |
D3–D5 | −59.5 ± 0.7*** | 4.3 ± 0.2*** | 14 | −85.8 ± 0.7*** | −4.7 ± 0.2* | 7 | 1.8 ± 0.1*** | 16.1 ± 0.5 | 12 |
D6 | −41.4 ± 1.0 | 7.0 ± 0.3 | 9 | −81.4 ± 1.7 | −6.8 ± 0.6* | 5 | 3.3 ± 0.2 | 26.5 ± 1.7*** | 9 |
Data shown are mean ± SEM from the number of cells shown in parentheses. Statistically significant differences are indicted (*p < 0.05; **p < 0.01; ***p < 0.001).