Table 1.

Effects of GLP-1 on firing rate, resting potential, and membrane resistance

ParameterControl100 nm GLP-1Washout
Resting potential (mV)−38 ± 1 (n = 7)−35 ± 1 (n = 7)*−38 ± 2 (n = 5)
Firing frequency (Hz)1.9 ± 0.6 (n = 7)3.3 ± 0.7 (n = 7)**2.9 ± 1.3 (n = 5)
Membrane resistance (GΩ)1.7 ± 0.2 (n = 7)1.4 ± 0.2 (n = 7)**1.6 ± 0.1 (n = 5)
Capacitance (pF)10 ± 1 (n = 7)
  • Parameters were measured from the same neuron first in control solution (ACSF), then in the presence of 100 nm GLP-1, and finally, 9 min after return to control solution. Numbers in parentheses give the number of cells from which data were recorded.

  • *p < 0.01 versus control;

  • **p < 0.05 versus control.