Male sexual behavior of gonad-intact and T-treated WT and GPR54 KO mice
| % Males mounting and thrusting | % Malesintromitting | % Males ejaculating | Mean latency to begin mounting (min) | Mean number of thrusting bouts | Mean number of intromission bouts | |
|---|---|---|---|---|---|---|
| Gonad-intact | ||||||
| Wild-type | 80 | 70 | 40 | 10.7 ± 1.5 | 6.1 ± 1.2 | 9.9 ± 1.7 |
| GPR54 KO | 0* | 0* | 0* | na | na | na |
| T-treated | ||||||
| Wild-type | 71 | 71 | 64 | 7.1 ± 1.8 | 4.9 ± 1.0 | 9.7 ± 2.7 |
| GPR54 KO | 83 | 67 | 17* | 8.8 ± 1.6 | 15.7 ± 3.4* | 9.3 ± 2.2 |
All male mice were paired with a hormone-primed sexually receptive female for 45 min. Gonad-intact GPR54 KO males did not display any sexual behavior. In contrast, castrated T-treated GPR54 KO males displayed mounting, thrusting, intromissions, and in the case of two animals, an ejaculation. Animal numbers were 10 animals per group (gonad-intact) and 12–14 animals per group (T-treated). *p < 0.05, significantly different from similarly treated WT males.na, Not applicable because gonad-intact KO males did not display any sexual behavior.