Histological diagnosis of wild-type and Nct+/− mice
| Nct+/− | Nct+/+ | ||
|---|---|---|---|
| Sick | Healthy | ||
| Hyperplasia (squamous, basal) | 29 of 29 | 1 of 6 | 1 of 15 |
| Neoplasia (total) | 17 of 29 | 5 of 6 | 3 of 15 |
| Squamous cell carcinoma | 14 of 29 | 0 of 6 | 0 of 15 |
| Broncho-alveolar carcinoma | 6 of 29 | 1 of 6 | 3 of 15 |
| Sarcoma | 1 of 29 | 3 of 6 | 0 of 15 |
| Hematopoietic (lymphoma, histiocytic sarcoma, mast cell tumor) | 1 of 29 | 2 of 6 | 0 of 15 |
Analysis was performed on 29 Nct+/− that have skin lesions, and 21 Nct+/+ mice were used as age-matched controls. Six of the 21 Nct+/+ mice appeared sick, and the other 15 appeared healthy. Most (90%) Nct+/− mice have more than one foci of tumors.