Statistical significance of differences between strength of resemblance to human HD caudate in various sets of genes: Emx-BDNF KO versus all other models
| System | Top 200 human changes | Top 400 human changes | Top 400 human decreases | Top 400 human increases | 127 Human striatal genes | Top 400 R6/2 changes |
|---|---|---|---|---|---|---|
| R6/2 | 1.17 (1.03–1.50) | 1.23 (1.07–1.62) | 1.31 (1.03–1.97) | 1.47 (1.29–1.87) | 1.20 (1.02–1.68) | 2.79 (1.81–4.53) |
| BDNF HET | 1.10 (1.02–1.17) | 1.09 (1.02–1.14) | 1.12 (1.04–1.18) | 0.99 (0.96–1.01) | 1.11 (0.99–1.19) | 1.04 (0.95–1.11) |
| 3NP | 1.19 (0.85–1.92) | 1.17 (0.89–1.77) | 0.94 (0.74–1.49) | 1.78 (1.35–2.58) | 1.56 (1.00–2.66) | 1.64 (1.21–2.53) |
| MPTP | 1.13 (1.03–1.24) | 1.12 (1.03–1.22) | 1.09 (1.01–1.16) | 1.13 (1.03–1.23) | 1.21 (1.05–1.37) | 1.11 (0.99–1.21) |
For each indicated set of gene, ratios of variances and 95% confidence intervals are reported. Numbers are bold if the model is less like human HD than the Emx-BDNF KO model and unity falls outside the 95% confidence interval. In those cases, the indicated model is significantly less like human HD than the Emx-BDNF KO model. Numbers are lightface if unity falls within the 95% confidence interval. In those cases, differences are considered indeterminate. It is important to note that there were no cases of a model being significantly more like human HD than the Emx-BDNF KO model.