Table 1.

Quantification of Iba-1⁺ cell numbers in the lumber spinal cord of mice with different CCR2 genetic background 14 d after peripheral nerve injury

	GFP chimeric mice		Peripheral CCR2KO mice	Central CCR2KO mice	CCR2KO mice
	A Iba-1⁺ cells	B GFP⁺ cells	C Iba-1⁺ cells	D Iba-1⁺ cells	E Iba-1⁺ cells
DHi	59.7 ± 2.75	16 ± 4.72	41.65 ± 2.09**	42.50 ± 3.63**	27.72 ± 2.1**
DHc	25.2 ± 3.83	3 ± 0.26	22.80 ± 1.56	20.90 ± 3.53	23.78 ± 1.33
VHi	56.55 ± 6.03	21.3 ± 8.1	33.05 ± 4.37**	42.20 ± 2.42*	26.02 ± 3.56**
VHc	28.65 ± 2.95	4 ± 1.67	26.80 ± 0.43	25.40 ± 2.92	26.94 ± 0.98

The number of Iba-1⁺ microglia was determined in four regions (DHi, DHc, VHi, and VHc) of the spinal cord (4–6 sections per mouse, 4 mice per group) in four groups (GFP chimeric, peripheral CCR2KO chimeric, central CCR2KO chimeric, and CCR2KO) of mice at 14 d after injury. Note that, on the ipsilateral side, the number of Iba-1⁺ cells was significantly less in mice lacking peripherally, centrally, or totally CCR2 receptor than that in GFP chimeric mice (data are expressed as mean ± SEM; *p < 0.05, **p < 0.01, peripheral, central, and total CCR2KO DHi/VHi vs GFP DHi/VHi, respectively).