Control | TLE | ||||
---|---|---|---|---|---|
Allopregnanolone | 10 nm | Baseline (n = 7) | Drug | Baseline (n = 5) | Drug |
τ | 21.7 ± 2.4 | 27.4 ± 2.0** | 21.9 ± 1.7 | 20.9 ± 0.8 | |
ampl | 39.95 ± 2.7 | 39.33 ± 7.7 | 57.12 ± 8.01 | 58.42 ± 13.6 | |
30 nm | (n = 12) | (n = 5) | |||
τ | 22.1 ± 3.3 | 40.9 ± 3.5** | 19.1 ± 1.9 | 20.0 ± 3.19 | |
ampl | 33.82 ± 1.4 | 38.55 ± 1.2 | 47.41 ± 2.4 | 54.66 ± 8.6 | |
100 nm | (n = 7) | (n = 4) | |||
τ | 27.8 ± 4.7 | 46.1 ± 2.2** | 35.6 ± 1.5 | 42.1 ± 2.2* | |
ampl | 37.37 ± 3.8 | 51.43 ± 5.9** | 65.3 ± 4.2 | 90.5 ± 11.1** | |
Diazepam | 30 nm | Naive (n = 6) | TLE (n = 6) | ||
τ | 13.9 ± 2.2 | 22.4 ± 2.3** | 24.9 ± 1.4 | 22.1 ± 1.06 | |
ampl | 62.06 ± 12.5 | 92.32 ± 13.8** | 92.08 ± 2.3 | 90.83 ± 1.6 | |
RO15-4513 | 300 nm | Naive (n = 7) | TLE (n = 8) | ||
τ | 23.9 ± 1.0 | 22.5 ± 1.3 | 23.7 ± 1.8 | 29.4 ± 1.9* | |
ampl | 43.2 ± 1.1 | 37.5 ± 0.6* | 61.83 ± 1.8 | 85.50 ± 1.2** | |
Furosemide | 100 μm | Naive (n = 8) | TLE (n = 6) | ||
τ | 24.3 ± 1.8 | 27.4 ± 1.6 | 38.1 ± 1.3 | 33.4 ± 1.1 | |
ampl | 55.8 ± 0.5 | 61.2 ± 0.7 | 59.1 ± 2.3 | 38.2 ± 1.5** |