Table 2.

Most significantly regulated gene categories

GO categoryp valuea
Second-messenger-mediated signaling1.62E-16
Intracellular signaling cascade3.89E-16
Protein kinase C activation1.45E-15
Muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway2.19E-15
Learning and/or memory1.91E-14
Positive regulation of mismatch repair6.61E-13
Negative regulation of protein ubiquitination6.61E-13
Negative regulation of protein modification6.61E-13
Regulation of mismatch repair6.61E-13
Dopamine transport8.71E-13
Wnt receptor signaling pathway1.41E-12
Regulation of cell differentiation1.91E-12
Negative regulation of enzyme activity2.45E-12
Negative regulation of biological process3.80E-12
Signal transduction1.10E-11
Cell communication2.14E-11
Negative regulation of protein amino acid phosphorylation2.82E-11
Negative regulation of amino acid metabolic process2.82E-11
Cell–cell signaling3.63E-11
Cell surface receptor-linked signal transduction3.89E-11
Regulation of developmental process4.37E-11
Regulation of peptidyl-tyrosine phosphorylation4.57E-11
Negative regulation of cellular process7.76E-11
Tissue remodeling9.12E-11
Regulation of signal transduction1.05E-10
  • ap values were calculated using Gene Go software with a false discovery rate cutoff of 0.01. Overall, 113 GO categories showed p values <1E-6, and 271 had p values <1E-4.