Table 1.

Phrenic short-term hypoxic response in burst amplitude and frequency in rats intrathecally injected with aCSF or 25 nm okadaic acid (25 nm OK)

TreatmentnΔ Burst amplitude (% baseline)Δ Burst frequency from baseline (bursts/min)
TC (aCSF)12−1 ± 5−3 ± 2
TC (25 nm OK)82 ± 40 ± 2
IH (aCSF)13108 ± 15*11 ± 3*
IH (25 nm OK)781 ± 13*14 ± 3*
SH (aCSF)1190 ± 13*9 ± 2*§
SH (25 nm OK)10126 ± 32*15 ± 3*
SH (25 nm OK, methysergide)665 ± 10*§9 ± 3*§
  • TC, Time control; OK, okadaic acid.

  • *Significantly different from baseline within treatment group.

  • Significantly different from TC (aCSF and 25 nm OK).

  • §Significantly different from SH (25 nm OK).