Table 2.

Genes in defined phagocytosis and engulfment pathways

Probe set IDAstrocytes (P7)Astrocytes (P17)Neurons (P16)Myelin oligosGene symbolGene title
1451086_s_at1283517817993719272Rac1 (ced-10)RAS-related C3 botulinum substrate 1
1421840_at1322911313443239Abca1 (ced-7)ATP-binding cassette, subfamily A (ABC1), member 1
1453771_at84077010569Gulp1 (ced-6)GULP, engulfment adaptor PTB domain containing 1
1429841_at474682681492340Megf10 (ced-1)Multiple EGF-like-domains 10
1448655_at46715922169386Lrp1 (ced-1)Low-density lipoprotein receptor-related protein 1
1448248_at5831660945785183Crk (ced-2)v-crk sarcoma virus CT10 oncogene homolog (avian)
1452220_at404038981751574Dock1 (ced-5)Dedicator of cyto-kinesis 1
1456098_a_at123241151553801Elmo2 (ced-12)Engulfment and cell motility 2, ced-12 homolog (C. elegans)
1422869_at194873705989Mertkc-mer proto-oncogene tyrosine kinase
1423586_at214525985243AxlAXL receptor tyrosine kinase
1417399_at50319911485268Gas6Growth arrest specific 6
1452784_at90181059517574162ItgavIntegrin α V
1417533_a_at85696783193231Itgb5Integrin β 5
1420911_a_at2501131089617754Mfge8Milk fat globule-EGF factor 8 protein
1417876_at36501136Fcgr1Fc receptor, IgG, high-affinity I
1435477_s_at48213254Fcgr2bFc receptor, IgG, low-affinity IIb
1448620_at24333472Fcgr3Fc receptor, IgG, low-affinity III
1418340_at21552280Fcer1gFc receptor, IgE, high-affinity I, gamma polypeptide
1450678_at55337979Cd11/Itgb2Integrin β 2
Reference cell-type-enriched genes
1440142_s_at9742138273177GfapGlial fibrillary acidic protein
1448768_at714624964MogMyelin oligodendrocyte glycoprotein
1433884_at32633918197239Syt1Synaptotagmin I
  • Molecular components of phagocytosis and engulfment pathways are enriched and expressed at high levels in astrocytes. See Results and Discussion for a complete description of the different pathways.