Table 3.

Effect of TBS on granule cell response properties

C57BL/6J (n = 5)C57 × Sv129 (n = 8)PrP0/0 slow (n = 4)
ΔAPprob (%)51.9 ± 2.3*55.7 ± 1.7**2.3 ± 1.7
ΔIth (%)−33.1 ± 21.2*−24.1 ± 21.0*8.75 ± 24.0
ΔRin-high (%)42.2 ± 15.8**55.5 ± 11.8**−12.6 ± 13.2
ΔRin-low (%)6.2 ± 7.90.39 ± 5.27.3 ± 10.1
TBSdep (mV)−44.3 ± 1.9*−44.6 ± 1.8*−34.1 ± 4.3

  • The table compares percentage changes in wild-type and PrP0/0 mice caused by TBS in current-clamp recordings: variation in probability of generating action potentials during synaptic stimulation (ΔAPprob), variation in current needed to reach spike threshold from the holding potential (ΔIth), variation in apparent input resistance in the region above or below −70 mV (ΔRin-high and ΔRin-low), and average depolarization during TBS (TBSdep). The number of observations is reported in parentheses, and statistical significance is reported in comparisons with slow-spiking PrP0/0 granule cells.

  • ↵*p < 0.05, **p < 0.01, unpaired t test.