Table 1.

Summary of basic electrophysiological properties, onset latencies, and durations of excitatory and inhibitory responses of BNST and VTA neurons to infralimbic cortex stimulation

BNST neurons projecting to the VTABNST neurons not projecting to the VTAVTA DA neurons
No. of neuronsn = 32n = 175n = 41
Spontaneously active neurons (%)4451100
Spontaneous firing rate (Hz)10.5 ± 2.69.8 ± 1.1a2.8 ± 0.25
Action potential width (ms)0.74 ± 0.040.82 ± 0.02a1.25 ± 0.04
Neurons responsive to tail pinch (%)21.820.7ND
Excitatory response to ILCx stimulation (percentage of neurons)81.2571.7086.11
Response magnitude of excitation for spontaneously active neurons (spikes)64.3 ± 12.955.8 ± 6.2a61.9 ± 10.1
Response magnitude of excitation for silent neurons (spikes)58.6 ± 11.654.2 ± 7.5aNA
Onset of excitation (ms)9.4 ± 0.711.5 ± 0.7a19.7 ± 1.2
Duration of excitation (ms)10.5 ± 1.013.3 ± 1.7a19.3 ± 2.1
Onset of inhibition (ms)10.9 ± 3.319.7 ± 3.6a44.3 ± 6.0
Duration of inhibition (ms)85.0 ± 29.7150.9 ± 20.4a99.8 ± 7.8
  • All values are means ± SEM. Response magnitudes were calculated as described in Materials and Methods. BNST neurons projecting to the VTA are those antidromicaly driven by the VTA stimulation. A two-tailed unpaired Student's t test was performed to compare the basic electrophysiological properties between the two populations of BNST neurons.

  • aNo significant differences between BNST neuronal populations. ND, Not determined; NA, not applicable.