Regions with significant effects of levodopa on learning-related neural responses
| Brain region | Coordinates (mm)a | Zmax | Cluster size | p valueb | ||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| Levodopa-mediated changes in activation/deactivation responsec | ||||||
| Loss of response | ||||||
| vmPFC (BA10) | −4 | 52 | 0 | 4.14 | 259 | <0.000 |
| Posterior insula | 48 | −14 | 4 | 4.21 | 839 | <0.000 |
| Recovery of responsed | ||||||
| PMC (BA 6) | −22 | 0 | 60 | 5.08 | 516 | <0.000 |
| Gain of responsed | ||||||
| preSMA (BA 6) | 14 | 6 | 72 | 3.57 | 47 | <0.000 |
↵aCoordinates are in MNI space.
↵bUncorrected values at peak voxel.
↵cSee text for classification of the significant treatment effects.
↵dSee supplementary Figure 3 (available at www.jneurosci.org as supplemental material) for illustration of the cerebral blood flow data in these regions.