The Bibliosphere application was used to coanalyze the microarray and transcription factor (TF) array data to yield information about gene transcription factor relations and, hence, gene expression regulators. Using this information, we have grouped TFs according to the type of expression effect they have (first column). +, Type of gene expression effect present, shown along each row defining the group. Shown is the transcription factor binding activity in STHdh cell lines in the Panomics array (calculated as a ratio of binding activity, or spot intensity in STHdh^111/111 vs STHdh^7/7 cell lines) (third column), and the number of gene changes in each of four groups (fourth through seventh columns). As an example, group 2 contains the transcription factors involved in regulating two groups of genes: the group of genes that are not expressed (absent) in wild-type STHdh^7/7 cell lines but expressed (present) in the homozygote STHdh^111/111 cell lines, and the group of genes that are downregulated in STHdh^111/111 cell lines (compared with levels in STHdh^7/7 cell lines). Transcription factors in this group do not have any other type of gene expression effects, although some of the genes are regulated by other transcription factors. So, within group 2, JunB regulates six genes that are absent in STHdh^7/7 and present in STHdh^111/111, and five genes that are downregulated in STHdh^111/111. Similarly, genes that are regulated by JunB can be regulated by other transcription factors, both in the same group and those in other groups. Specifically, one of the downregulated genes in STHdh^111/111 cell lines, Tgfb1 is regulated by JunB, but also regulated by the transcription factors Creb1 (group 1), Stat6 (group 2), and Pgr (group 8), among others. However, within gene expression patterns, each gene is uniquely assigned to a type of gene expression (i.e., if it is downregulated in STHdh^111/111, then it cannot belong to the group of genes that are upregulated in STHdh^111/111); thus, each factor that is known to regulate a gene is correlated with the same type of expression effect. Crebbp, CREB binding protein; Pparg, peroxisome proliferator activated receptor gamma; Pgr, progesterone receptor; Rara, retinoic acid receptor A; Rarb, retinoic acid receptor B; Tbp, TATA-box binding protein; Srf, serum response factor; Vdr, Vitamin D receptor.