Antagonist (concentration) | Target receptor | Antagonist of Vc1.1 inhibition | Percentage inhibition of IBa by Vc1.1 (n) |
---|---|---|---|
Mecamylamine (3 μm) | nAChR | − | 29.2 ± 8.6 (3) |
ACh (100 μm) | nAChR | − | 28.4 ± 4.5 (7) |
Atropine (1 μm) | mAChR | − | 27.2 ± 10.4 (4) |
Prazosin (10 μm) | α1-Adrenergic | − | 41.3 ± 4.8 (3) |
Yohimbine (10 μm) | α2-Adrenergic | − | 35.8 ± 11.5 (3) |
Naloxone (10 μm) | μ-Opioid | − | 50.1 ± 12.4 (3) |
Bicuculline (30 μm) | GABAA | − | 32.9 ± 7.0 (10) |
Phaclofen (50 μm) | GABAB | + | 4.6 ± 4.4 (9) |
CGP 55845 (1 μm) | GABAB | + | 6.8 ± 4.5 (14) |
CGP 54626 (1 μm) | GABAB | + | 7.4 ± 2.3 (4) |
+, Reversal of Vc1.1 inhibition; −, no effect; mAChR, muscarinic acetylcholine receptor.