Table 2.

Significant changes in caudate functional connectivity for l-dopa, relative to placebo (min Z >2.3; cluster significance: p < 0.05, corrected), as shown in Figures 3 and 4

mm3BAPeak voxel
xyz
l-Dopa-related increases in functional connectivity
    L VSiBL cerebellum (lobules IV, V, VI), cerebellar vermis (lobule VI), brainstem (pons)1135−12−32−36
R inferior frontal gyrus, anterior insula, superior temporal gyrus70944, 45, 6, 22, 3850262
L globus pallidus577−30−266
BL cerebellum (lobules V, VI, IX, crus I)512−10−66−16
l-Dopa-related decreases in functional connectivity
    R DCBL PCC202923, 26, 30, 310−4038
BL ventromedial prefrontal cortex98410, 32−240−14
    L VSsBL PCC, medial occipital cortex155923, 26, 30, 31, 1918−4826
    R VSsBL PCC, medial occipital cortex221223, 26, 30, 31, 19−4−6624
    L VSiBL PCC, medial occipital cortex254623, 26, 30, 31, 17, 18, 190−80−2
    R VSiBL PCC, medial occipital cortex187626, 29, 30, 17, 18 19−14−606
  • BA, Brodmann area; BL, bilateral; L, left; R, right.