Table 3.

Significant differences between sessions recorded after 25 h (MSD) and 14 h (ESD) of wakefulness in brain activity related to the 3-back task in PER3^4/4 and PER3^5/5 genotypes

Brain areas	Side	X, Y, Z	Brodmann's area	Z	p_corrected value
Increase in brain activity in PER3^4/4 (MSD > ESD)
Thalamus (a)	L	−6, −12, 8		3.10	0.039 ^¶
Parahippocampus (b)	L	−24, −42, −10		3.13	0.036 ^¶
Cerebellum (c)	L	−30, −76, −26		3.26	0.026 ^¶
Decrease in brain activity in PER3^4/4 (MSD < ESD)
No significant voxels (p _uncorrected < 0.001)
Increase in brain activity in PER3^5/5 (MSD > ESD)
No significant voxels (p _uncorrected <0.001)
Decrease in brain activity in PER3^5/5 (MSD < ESD)
Inferior frontal gyrus (d)	L	−54, 32, 12	46	4.75	0.038 ^¶
Inferior frontal gyrus/middle frontal gyrus (e)	R	46, 32, 4	46	4.67	0.05 ^¶
	R	44, 32, 14	46	3.93	0.003
	R	40, 18, 22	44/45	3.92	0.004
Superior frontal sulcus	L	−22, 54, 0	10	3.60	0.010
Superior parietal cortex (f,g)	L	−24, −54, 62	7	3.87	0.004
	L	−26, −64, 56	7	3.80	0.005
	R	24, −52, 60	7	3.48	0.018
	R	14, −54, 66	7	3.33	0.022 ^¶
Postcentral gyrus/anterior intraparietal sulcus (h,i)	R	42, −32, 40	40	4.08	0.002
	L	−38, −24, 42	40	3.39	0.018
Superior temporal sulcus (j,k)	L	−52, 12, −26	21	4.85	0.026 ^¶
	L	−52, −48, 8	21/22	4.65	< 0.001 ^¶
	R	52, −36, −8	21	4.02	0.003 ^¶
Middle occipital gyrus (l,m)	R	30, −86, −4	19	4.42	0.002 ^¶
	R	32, −84, 10	19	3.63	0.009 ^¶
	L	−38, −72, −2	19/37	4.36	0.001 ^¶
	L	−24, −86, −4	18	4.12	0.001 ^¶
	L	−22, −76, 18	19	3.47	0.015 ^¶
Fusiform gyrus	R	42, −58, −18	19/37	4.07	0.002 ^¶
	R	28, −66, −12	19	3.67	0.008
Cingulate cortex (n)	L	−10, −18, 36	24/31	3.87	0.004 ^¶
	R	16, 46, 10	32	3.43	0.016
Insula (o)	L	−38 −10 12		3.73	0.007
Putamen (p)	L	−22, 2, 2		3.50	0.013 ^¶
Globus pallidus	R	20, 0, 0		3.35	0.020 ^¶

Letters in parentheses (a–v): Reference to Figure 4. L, Left; R, right.
↵ ^¶Significant interaction between session and genotype: [(MSD > ESD) * (PER3^4/4 > PER3^5/5 )].