Summarizes the pathologies of the APPSwDI/NOS2−/− and the APPSw/NOS2−/− mice aged 12 months, the age at the beginning of this study
| Mouse | Amyloid deposition (% area) | Aβ ELISA (pg/mg protein) | AT8-positive tau | Neuron loss (%) | |||||
|---|---|---|---|---|---|---|---|---|---|
| FCX | HPC | SUB | Total soluble | Total insoluble | Total Aβ40 | Total Aβ42 | |||
| APPSw/NOS2−/− | 5.8 ± 0.6 | 4.9 ± 0.3 | 1.6 ± 0.2 | 291 ± 126 | 2881 ± 960 | 2480 ± 800 | 880 ± 250 | Extensive | 30–35 |
| APPSwDI/NOS2−/− | 16.7 ± 1.9 | 18.5 ± 3 | 18.6 ± 4.4 | 1200 ± 61 | 27,544 ± 4500 | 27,000 ± 4400 | 1700 ± 225 | Extensive | 35–40 |
FCX, Frontal cortex; HPC, hippocampus; SUB, subiculum.