Table 2.

Genes that are upregulated by inosine in CSNs contralateral to cortical injury and in retinal ganglion cells undergoing axon regeneration in vivo

ProbeSymbolDefinitionFold induction
CSMNsaRGCsb
ILMN_53325LOC498335(P) Small inducible cytokine B13 precursor (CXCL13)11.423.97
ILMN_70335A2mα-2-Macroglobulin4.102.36
ILMN_62559Timp1Tissue inhibitor of metalloproteinase 13.7413.00
ILMN_51277LOC305633(P) Antxr2 protein3.134.82
ILMN_60046Serping1Serine (or cysteine) peptidase inhibitor, clade G, member 12.934.63
ILMN_48088Ifitm3(P) Interferon induced transmembrane protein 32.741.99
ILMN_55502C1qgComplement component 1, q subcomponent, γ polypeptide2.732.62
ILMN_53575Mt1aMetallothionein2.696.02
ILMN_58058Lcp1(P) Lymphocyte cytosolic protein 12.682.07
ILMN_60003Cd68(P) CD68 antigen2.623.34
ILMN_60037Lgals3bpLectin, galactoside-binding, soluble, 3 binding protein2.603.03
ILMN_68224Gfap(P) Glial fibrillary acidic protein2.465.10
ILMN_57422Serpinb1a(P) Serine (or cysteine) proteinase inhibitor, clade B, member 1a2.412.93
ILMN_55731BzrpBenzodiazepine receptor, peripheral2.382.43
ILMN_47707Aif1Allograft inflammatory factor 12.332.33
ILMN_69642Arpc1bActin related protein 2/3 complex, subunit 1B2.312.48
ILMN_59412Emp3Epithelial membrane protein 32.202.16
ILMN_48069Crabp2Cellular retinoic acid binding protein 22.128.63
ILMN_67382Cd63CD63 antigen (Cd63)2.103.03
ILMN_55706C1sComplement component 1, s subcomponent2.032.03
ILMN_67686Ms4a6bMembrane-spanning 4-domains, subfamily A, member 6B2.032.22
ILMN_61063Rhoc(P) Ras homolog gene family, member C2.022.71
ILMN_54242VimVimentin1.962.69
ILMN_55431Rnaset2(P) Ribonuclease T21.881.79
ILMN_62651Eif4ebp1Eukaryotic translation initiation factor 4E binding protein 11.862.39
ILMN_58496C1qaComplement component 1, q subcomponent, α polypeptide1.841.66
ILMN_53085Irf1Interferon regulatory factor 11.831.61
ILMN_62100Ftl1Ferritin light chain 11.742.28
ILMN_59774Ppp1r14bProtein phosphatase 1, regulatory (inhibitor) subunit 14B1.743.36
ILMN_59161Npc2Niemann Pick type C21.732.38

  • (P), Predicted.

  • ↵aFold change over and above the effect of inosine of decreasing stroke-induced changes.

  • ↵bBased on comparison between active regeneration state (induced by macrophage-derived factors) and normal control RGCs collected by fluorescence-activated cell sorting. From Fischer et al. (2004) (supplemental data, available at www.jneurosci.org as supplemental material).