Volume differences between women and men
| Structure | Corrected for sample | Corrected for sample and ICV | Corrected for sample and TBV | |||
|---|---|---|---|---|---|---|
| Difference (z) | t (p) | Difference (z) | t (p) | Difference (z) | t (p) | |
| 3rd ventricle | −0.455 | −7.761 (<10−13) | −0.189 | −3.154 (<0.01) | −0.703 | −12.458 (<10−32) |
| 4th ventricle | −0.354 | −5.978 (<10−08) | −0.054 | −0.893 (>0.05n.s.) | −0.271 | −4.540 (<10−06) |
| Accumbens | −0.327 | −5.506 (<10−07) | −0.043 | −0.722 (>0.05n.s.) | 0.131 | 2.190 (<0.05) |
| Amygdala | −0.838 | −15.283 (<10−47) | −0.253 | −4.247 (<10−03) | −0.083 | −1.377 (>0.05n.s.) |
| Brainstem | −0.902 | −16.731 (<10−55) | −0.268 | −4.490 (<10−04) | −0.294 | −4.948 (<10−6) |
| Caudate | −0.586 | −10.164 (<10−22) | 0.007 | 0.121 (>0.05n.s.) | −0.034 | −0.561 (>0.05n.s.) |
| Cerebellum cortex | −0.889 | −16.432 (<10−53) | −0.363 | −6.143 (<10−07) | −0.169 | −2.824 (<0.005) |
| Cerebellum WM | −0.626 | −10.938 (<10−25) | −0.041 | −0.682 (>0.05n.s.) | −0.014 | −0.225 (>0.05n.s.) |
| Cerebral cortex | −0.830 | −15.114 (<10−46) | −0.238 | −3.988 (<10−03) | 0.159 | 2.658 (<0.01) |
| Cerebral WM | −0.914 | −17.009 (<10−57) | −0.013 | −0.222 (>0.05n.s.) | −0.093 | −1.556 (>0.05n.s.) |
| CSF | −0.483 | −8.264 (<10−15) | −0.107 | −1.781 (>0.05n.s.) | −0.472 | −8.067 (<10−14) |
| Hippocampus | −0.719 | −12.785 (<10−34) | −0.169 | −2.821 (<0.005) | 0.125 | 2.088 (<0.05) |
| Inferior lateral ventricle | −0.228 | −3.808 (<10−02) | −0.072 | −1.194 (>0.05n.s.) | −0.565 | −9.785 (<10−21) |
| Lateral ventricle | −0.315 | −5.306 (<10−06) | −0.016 | −0.259 (>0.05n.s.) | −0.559 | −9.665 (<10−20) |
| Pallidum | −0.724 | −12.872 (<10−34) | −0.197 | −3.292 (<0.005) | −0.123 | −2.046 (<0.05) |
| Putamen | −0.597 | −10.386 (<10−23) | −0.166 | −2.765 (<0.01) | 0.040 | 0.666 (>0.05n.s.) |
| Thalamus | −0.820 | −14.904 (<10−45) | −0.124 | −2.065 (<0.05) | 0.055 | 0.922 (>0.05n.s.) |
| Total brain volume | −0.988 | −18.798 (<10−68) | −0.216 | −3.615 (<0.001) | NA | NA |
t test of mean differences in volume are presented for the various brain structures included in the present paper. Results are shown for analyses done on the residuals after the effect of sample is regressed out, when the effects of sample and ICV are regressed out, and finally when the effects of sample and total brain volume are regressed out. Negative difference score and t value indicate larger volume for men and positive indicate larger for women. Men had significantly larger uncorrected volumes for all structures and significantly larger ICV-corrected volumes for 10 structures. n.s., Not significant; NA, not applicable.