Bivariate correlations between mean 5-HTT binding and FDG-PET values
| Brain region | Hemisphere | 5-HTT availability correlations with NEC glucose metabolism (n = 34) | Coordinates (relative to AC) | |||
|---|---|---|---|---|---|---|
| Pearson's r | p (two-tailed) | x | y | z | ||
| Amygdalohippocampal area | Left | 0.292 | 0.094 | −8.75 | −3.75 | −9.375 |
| BNST | Left | 0.195 | 0.270 | −3.75 | −0.625 | 1.875 |
| Hippocampus | Left | 0.254 | 0.147 | −14.375 | −7.5 | −10 |
| Genu of corpus callosum | Midline | 0.447 | 0.008 | 0 | 10.625 | 6.875 |
| Amygdalohippocampal area | Right | 0.479 | 0.004 | 7.5 | −3.75 | −11.25 |
| BNST | Right | 0.377 | 0.028 | 3.75 | 0.625 | 0.625 |
| Hippocampus | Right | 0.067 | 0.707 | 13.75 | −6.875 | −11.25 |
Mean 5-HTT values were extracted from each brain region of interest and residualized for the effects of age, gray matter probability, and DASB injection mass. Mean FDG values were extracted from each brain region of interest and residualized for the effects of age and gray matter probability. The FDG values were taken from the NEC component of the behavioral paradigm and therefore represent glucose metabolism in response to a potential threat. AC, Anterior commissure.