The effects of cannabinoid receptor agonists and antagonist microinjected into the BLA on locomotion and anxiety in the open-field test
| Vehicle (n = 6) | AM404 (n = 6) | WIN55,212-2 (n = 6) | AM251 (n = 6) | |
|---|---|---|---|---|
| Time in center (s) | 7.83 ± 1.25 | 6.33 ± 1.31 | 4.66 ± 1.08 | 4.5 ± 1.28 |
| Time in periphery (s) | 292.16 ± 1.25 | 293.66 ± 1.31 | 295.33 ± 1.08 | 295.5 ± 1.28 |
| Number of rearing events | 20.33 ± 1.74 | 21.66 ± 2.03 | 22 ± 1.69 | 19.16 ± 2.10 |
| Distance covered (s) | 1758.33 ± 114.32 | 1916.66 ± 158.46 | 1675 ± 107.04 | 1729.16 ± 231.16 |
Rats microinjected into the BLA with the CB1 receptor antagonist (AM251, n = 6), one of the agonists (WIN55,212-2 or AM404, n = 6 each), or vehicle (n = 6) showed no differences in any of the parameters measured in the open-field test.