Table 4.

Brain networks associated with the analgesia-related peak in OFC and the RIII-modulation peak in the PAG (directed search)

Brain area	Regions coactivated with analgesia-related OFC				Regions coactivated with RIII-modulation peak in the PAG
Brain area	BA^{^a}	Side^{^b}	t	x, y, z^{^c}	BA^{^a}	Side^{^b}	t	x, y, z^{^c}
Postcentral gyrus (SI)	—	—	—	—	1–3	R	9.29	3, −48, 70
PCL	—	—	—	—	5	R	7.83	−3, −41, 50
Motor cortex
SMA	—	—	—	—	6	—	10.67	0, −10, 70
Pre-SMA	—	—	—	—	6/8	—	11.08	0, 17, 65
Cingulate cortex
ACC	24/32	L	8.29	−7, 10, 40	32	R	6.22	10, 7, 45
	32	L	5.65	−7, 21, 35	32	—	8.11	−3, 38, 20
	24/32	R	7.81	10, 21, 30	—	—	—	—
	32	—	6.61	0, 31, 25	—	—	—	—
Subgenual ACC	32	—	8.10	−3, 24, −10	—	—	—	—
PCC	23	—	6.73	0, −31, 25	23	L	6.29	−10, −24, 40
	—	—	—	—	31	R	6.23	−7, −48, 30
Retrosplenial cortex	—	—	—	—	30	—	10.05	−3, −45, 10
aINS	—	L	6.78	−45, 7, −5	—	—	—	—
PHG	37	L	5.90	−24, −41, −10	35	R	8.12	21, −17, −30
	36	R	6.10	34, −10, −20	35	R	6.97	17, −31, −10
AMY/PHG	—	L	6.70	−31, −3, −20	—	—	—	—
PFC
Medial frontal gyrus	10/32	L	9.36	−7, 45, −15	9	—	9.23	−3, 45, 30
	—	—	—	—	9	L	11.23	−10, 52, 25
	—	—	—	—	10	R	11.12	7, 62, 15
Inferior frontal gyrus	47	L	8.56	−45, 21, −15	9	L	11.80	−55, 7, 30
	47	L	7.86	−41, 14, −10	46	L	7.84	−45, 45, 10
	46	L	6.42	−52, 34, 15	46	R	8.27	52, 41, 10
Middle frontal gyrus	10	L	6.50	−45, 45, 15	46	L	8.23	−41, 34, 25
	46	R	7.43	48, 17, 25	9	R	9.00	52, 7, 40
	10	R	6.94	31, 45, 25	9	R	7.40	31, 34, 33
	10	R	6.31	38, 48, 0	10	R	7.27	45, 52, 5
	—	—	—	—	10	R	5.89	41, 58, 0
Superior frontal gyrus	9	R	6.61	38, 34, 35	10	R	10.21	31, 62, 20
OFC	11	R	10.30	28, 34, −15	—	—	—	—
	11	R	9.97	21, 21, −15	—	—	—	—
	11	R	7.78	17, 34, −20	—	—	—	—
Thalamus	—	—	—	—	—	L	7.06	−3, −14, 10
	—	—	—	—	—	L	6.86	−17, −21, 15
	—	—	—	—	—	R	8.20	7, −14, −10
Pons	—	—	—	—	—	L	6.91	−7, −24, −35
	—	—	—	—	—	R	6.13	10, −28, −40
Pons/medulla (RVM)	—	—	—	—	—	—	8.15	−3, −24, −45

Peaks of activity were thresholded at p < 0.05 corrected for multiple comparisons for the search volume, using the random-field theory, minimum 3 voxels per cluster.
↵^aBA, Putative Brodmann area.
↵^bR, right ipsilateral side; L, left contralateral side.
↵^cCoordinates are reported in MNI space.