Effect of Ro15–4513 on GABAA-R-mediated sIPSCs in granule cells of the dentate gyrus during pregnancy and after delivery
| Group (n) | Amplitude (% change) | Decay time (% change) | Area (% change) | Frequency (% change) |
|---|---|---|---|---|
| E (5) | −5.5 ± 7.2 | −24.1 ± 4.1* | −31.2 ± 9.5* | −11.2 ± 7.3 |
| P19 (8) | −10.3 ± 6.8 | −19.5 ± 5.2* | −23.1 ± 10.3* | −3.6 ± 6.9 |
| pp2 (8) | 12.2 ± 10.2 | 28.6 ± 8.3* | 25 ± 11.5 | −5.8 ± 7.7 |
Data are expressed as the percentage of change in current parameters induced by Ro15-4513 (3 μm) and are means ± SEM for the indicated numbers (n) of neurons in hippocampal slices obtained from rats in estrus, at day 19 of pregnancy, or at 2 d after delivery.
↵*p < 0.05 versus estrus (one-way ANOVA followed by Scheffe's test).