Mean ± SEM elapsed time during object recognition testing
| Age | Delay | Treatment | Elapsed time (s) |
|---|---|---|---|
| Middle-aged | 24 h | Vehicle | 387.95 ± 71.07 |
| IH U0126 | 471.91 ± 135.11 | ||
| Middle-aged | 24 h | IH LY294002, 0.0005 μg | 270.22 ± 31.47 |
| IH LY294002, 0.005 μg | 291.88 ± 52.51 | ||
| IH LY294002, 0.5 μg | 468.25 ± 64.55 | ||
| Middle-aged | 48 h | Vehicle | 342.43 ± 58.42 |
| ICV E2 | 489.92 ± 76.78 | ||
| IH E2 | 455.91 ± 110.46 | ||
| ICV E2 + IH U0126 | 402.75 ± 79.37 | ||
| ICV E2 + IH LY294002 | 441.78 ± 67.32 | ||
| Aged | 48 h | Vehicle | 322.61 ± 29.73 |
| ICV E2 | 297.73 ± 39.48 | ||
| IH E2 | 294.25 ± 58.36 |
ICV, Intracerebroventricular; IH, intrahippocampal.