Study | Method of reducing OB neurogenesis | Impact on immatureadult-generated neurons | Impact on mature adult-generatedneurons | Odordiscrimination | Odor memory |
---|---|---|---|---|---|
Gheusi et al., 2000 | NCAM−/− | Migration in RMS: impaired | GCL width: 35% reduction | Impaired | Impaired short-term(80–100 min) |
Enwere et al., 2004 | Aging, Lifr+/−, TGFαwa1/wa1 | BrdU+/calretinin+ cells (4 wkpostinjection): 59% reductionin GL in aged mice | BrdU+/GABA+ cells (4 wk postinjection):41% reduction in GL, 55% reductionin GCL in aged mice | Impaired | |
Bath et al., 2008 | BDNF+/−, TrkB+/−, BDNFMet/Met | Proliferation: no change | BrdU+ cells in GCL (4 wk postinjection):30% reduction | Impaired | |
Imayoshi et al., 2008 | Nestin-CRE-ERT2 × NSE-DTA | DCX+ cells in RMS: reduced | NeuN+ cells in GCL: 10% reduction | No deficit | No deficit |
Lazarini et al., 2009 | Focal SVZ irradiation | DCX+ cells in GL and GCL:70% reduction | No deficit | Impaired long-term(30 d) | |
Breton-Provencheret al., 2009 | LV AraC infusion | DCX+ cells in GCL:75% reduction | NeuN+ cells in GCL: no change | No deficit | Impaired short-term(60–120 min) |
BrdU, Bromodeoxyuridine; CRE, cAMP response element; GCL, granule cell layer; GL, glomerular layer; LV, lateral ventricle; RMS, rostral migratory stream; SVZ, subventricular zone.