Series of severe seizures precipitating SUDEP in a Kcna1 −/− mouse
| Time of day | Seizure duration (s) | Postictal heart rate (bpm) | ECG abnormalities |
|---|---|---|---|
| 5:41 P.M. | 150 | 630 | First extended seizure in series; no obvious ECG abnormalities during seizure |
| 7:00 P.M. | 124 | 560 | During 2nd seizure, severe bradycardia/asystole with heart rate decreasing to 100 bpm for 9 s (see Fig. 3 A) |
| 7:52 P.M. | 184 | 490 | During 3rd seizure, severe bradycardia/asystole with heart rate decreasing to 90 bpm for 20 s (see Fig. 3 B) |
| 8:49 P.M. | 231 | 400 | During 4th seizure, severe bradycardia/asystole with heart rate decreasing to 210 bpm for 8 s; shortly afterwards, ambulatory movement ceased (see Fig. 3 C) |
| 9:57 P.M. | 277 | 380 | During 5th seizure, one AV block; afterwards, ECG showed variable bradyarrhythmias (∼180–360 bpm) and asystoles until electrical silence |