Conotoxin MII rat plasma protein and brain tissue binding determined at 10 μg/ml and 10 μg/g, respectively, after 5 h incubation on a 96-well equilibrium dialysis plate (HTDialysis)
Matrix (Lister hooded rats)
fu%
Brain
Plasma
Values
7.09
49.61
5.92
57.35
9.13
56.96
9.71
55.45
7.79
49.83
7.57
47.58
Mean
7.87
>50
SD
1.38
NM
Median
7.68
>50
Range
[5.92–9.71]
[47.58 to >50]
Abbreviations: fu, Fraction unbound; NM, not measurable.