Inhibitory neurons in subcortical regions of Fgfr2 cKO mice were significantly decreased in density compared with Cre− controls
| Fgfr2 control density (×103/mm3) | Fgfr2 cKO density (×103/mm3) | Difference | |
|---|---|---|---|
| BST GABA | 84.73 ± 7.48 | 17.35 ± 7.48 | −79.5% |
| (n = 3) | (n = 3) | (p < 0.005) | |
| Septum GABA | 68.45 ± 4.49 | 25.70 ± 9.81 | −62.5% |
| (n = 3) | (n = 3) | (p < 0.01) | |
| BST calretinin | 31.68 ± 5.44 | 14.70 ± 2.56 | −53.6% |
| (n = 7) | (n = 6) | (p < 0.01) | |
| Septum calretinin | 20.37 ± 2.56 | 12.47 ± 2.14 | −38.8% |
| (n = 7) | (n = 6) | (p < 0.05) | |
| BST somatostatin | 5.09 ± 0.40 | 2.34 ± 0.56 | −48% |
| (n = 3) | (n = 3) | (p < 0.01) | |
| Septum somatostatin | 5.83 ± 1.90 | 5.19 ± 0.50 | −11.0% |
| (n = 3) | (n = 3) | (NS) | |
| BST calbindin | 21.28 ± 5.63 | 14.93 ± 5.67 | −29.8% |
| (n = 3) | (n = 3) | (NS) | |
| Septum calbindin | 12.92 ± 3.65 | 8.05 ± 0.82 | −37.7% |
| (n = 3) | (n = 3) | (NS) | |
| BST parvalbumin | 1.49 ± 0.44 | 1.49 ± 0.52 | 0.5% |
| (n = 5) | (n = 3) | (NS) | |
| Septum parvalbumin | 2.88 ± 0.48 | 2.54 ± 0.28 | −11.9% |
| (n = 3) | (n = 3) | (NS) |
Number of inhibitory neurons types obtained by stereological analyses (±SEM) in 3-month-old animals.
Values of p were obtained from two-tailed, unpaired Student's t test.