Minimal levodopa exposure required for the development of altered motor responses after transgenic ΔFosB expression
| rAAV-ΔFosB | Chronic l-dopa treatment Total l-dopa injectionsb | ||
|---|---|---|---|
| Total l-dopa injectionsa | Tests after viral infusions | ||
| Limb dyskinesias | 2 | 1 | 15 |
| Hypersensitivity | 3 | 2 | 15 |
↵aTotal exposure to levodopa includes the baseline test performed the day before the viral vector infusion. Note that limb dyskinesias appeared at the first levodopa test after virus infusion (week 4) and with a total of two levodopa injections.
↵bLimb dyskinesias consistently developed at the end of the first week of chronic treatment (injection 15 on the morning of day 8 after 1 week of twice daily injections).