PLP139-151 induced EAE in CXCR2+/+ and CXCR2−/− bone marrow radiation chimeric mice a
| Mice | Incidence b | Mortality | Day of onset | Day of peak EAE | Mean max score | Cumulative EAE score |
|---|---|---|---|---|---|---|
| Cxcr2 +/−→Cxcr2 +/+ | 19/22 (86%) | 1/22 (5%) | 12.3 ± 2.5 | 13.3 ± 3.1 | 3.4 ± 1.1 | 27 ± 13.9 |
| Cxcr2 +/−→Cxcr2 −/− | 15/17 (88%) | 0/17 (0%) | 13.9 ± 2.8 | 14.6 ± 2.1 | 3.3 ± 0.9 | 17 ± 8.7* |
Mean max score, Mean maximum EAE score. Data represent pooled results from three experiments.
↵ a Bone marrow radiation chimeras were done by transferring 1 × 107 bone marrow cells from CXCR2+/− mice to 900 rad irradiated CXCR2+/+ and CXCR2−/− recipients.
↵ b Five CXCR2−/− recipients that died within day 7 p.i. were not calculated as total number for incidence.
↵*p < 0.05, compared with the wild-type recipients.