Table 2.

Analysis of neuroactive steroids levels by LC–MS/MS in plasma of control, STZ, and STZ rats treated with GW3965

	PREG	PROG	DHP	THP	Isopregnanolone	DHEA	T	DHT	3α-diol
Control	0.64 ± 0.07	0.82 ± 0.12	1.22 ± 0.11	0.49 ± 0.10	0.33 ± 0.10	0.059 ± 0.007	4.12 ± 0.57	0.065 ± 0.006	1.63 ± 0.27
STZ	0.32 ± 0.09^*	0.28 ± 0.05^**	0.83 ± 0.04^*	0.36 ± 0.12	0.28 ± 0.09	0.058 ± 0.009	0.70 ± 0.021^**	0.064 ± 0.01	0.54 ± 0.13^**
STZ + GW3965	0.29 ± 0.03^*	0.68 ± 0.19	0.78 ± 0.16^*	0.75 ± 0.17	0.68 ± 0.19	0.065 ± 0.008	0.25 ± 0.08^**	0.055 ± 0.005	0.71 ± 0.21^*

Data are expressed as pg/μl of plasma and are represented by mean ± SEM. Control, n = 8; STZ, n = 8; STZ + GW3965, n = 6. Statistical analysis was performed by one-way ANOVA followed by Tukey–Kramer posttest.
↵*p < 0.05,
↵**p < 0.001 versus control rats.