Quantification of experimental results: combined GAT1 plus GAT3 antagonists
| NO-711 | NO-711 + SNAP | Wash (NO-711) | p (control vs drug) | |
|---|---|---|---|---|
| Amplitude (pA) | 106 ± 43 | 81 ± 23 | 106 ± 43 | p = 0.56 |
| Half-width (ms) | 183 ± 14 | 2139 ± 583 | 183 ± 14 | p < 0.05 |
| Fast τ (ms) | 109 ± 10 | 56 ± 23 | 109 ± 10 | p = 0.13 |
| Slow τ (ms) | 872 ± 121 | 2719 ± 421 | 872 ± 121 | p < 0.01 |
| τdw (ms) | 239 ± 31 | 2468 ± 426 | 239 ± 31 | p < 0.01 |
IPSCs during GAT1 and GAT3 antagonism. Shown are raw values of several parameters measured from evoked GABAB IPSCs during GAT1 plus GAT3 (n = 5) blockade. All statistical measures shown describe control versus experimental comparisons using paired t test analyses.