Significant decreases in rCBF on the higher dose of SYN115 compared with placebo
| Cluster | Volume of cluster (in ml) | Peak t value (11 df) | Location of peak t value | Anatomic description of cluster |
|---|---|---|---|---|
| 1 | 51.4 | 19.51 | Right dorsomedial thalamus | Bilateral thalamus, precuneus (BA 7, 23, 31), midbrain, cuneus (BA 7, 18), posterior cingulate (BA 23, 29, 30) |
| 2 | 12.1 | 14.27 | Right anterior cingulate cortex (BA 32) | Bilateral anterior cingulate (BA 32), medial frontal gyrus (BA 9, 11) |
| 3 | 9.7 | 9.59 | Left prefrontal cortex (lateral to BA 32) | Left middle and inferior gyri (BA 8, 9, 45, 46), precentral gyrus (BA 44) |
| 4 | 8.7 | 7.74 | Left middle frontal gyrus (BA 6) | Left middle and precentral gyri (BA 6, 4) |
| 5 | 2.8 | 6.81 | Right postcentral gyrus (BA 2) | Right postcentral gyrus (BA 2) |
| 6 | 2.8 | 6.71 | Left superior parietal lobule (BA 7) | Left superior parietal lobule (BA 7) |
| 15 | 1.4 | 5.45 | Right precentral gyrus (BA 6) | Right precentral and medial frontal gyri (BA 6) |
| 22 | 0.9 | 4.90 | Right medial frontal gyrus (BA 9) | Right medial frontal gyrus (BA 9) |
See supplemental Table 3 (available at www.jneurosci.org as supplemental material) for additional details.