Table 2.

Regions in ApoE4+ versus ApoE4− participants with significantly different connectivity of the bilateral precuneus to a priori regions

Regions	(x, y, z)	Voxels	p Value
Regions	(x, y, z)	Voxels	Uncorrected	Corrected
Left superior temporal gyrus/fronto-parietal operculum (BA22)	−37, −40, +9	21	0.001	0.009^*
Right superior temporal gyrus/fronto-parietal operculum (BA22)	+51, −3, +8	13	0.006	0.082
Left hippocampus and parahippocampus	−17, −34, −12	43	<0.001	0.005^*
Dorsal anterior cingulate (BA32)	−14, +18, +30	27	<0.001	0.006^*
Caudal orbital cortex	−13, +24, −16	32	<0.001	0.004^*
Pregenual anterior cingulate (BA24)/striatum	−02, +24, +02	19	0.013	0.179
Middle temporal cortex (BA20)	+58, −12, −22	70	0.002	0.028^*
Right parahippocampus	+31, −30, −14	17	0.007	0.102
Right hippocampus	+19, −19, −6	14	<0.001	0.004^*
Medial prefrontal cortex (frontal pole) (BA10)	+16, +53, +18	15	0.001	0.020^*
Inferior orbital cortex (BA11)	+7, +58, −21	13	0.004	0.054
Gyrus rectus (BA11)	+4, +23, −21	11	0.001	0.014^*
Hypothalamus	0, 0, −9	15	0.012	0.168
Dorsal occipital cortex (BA19)	0, −89, +40	27	0.002	0.029^*

Regions were derived from comparisons of a priori areas shown in supplemental Figure 1 (available at www.jneurosci.org as supplemental material) and are shown in Figures 1 and 2. Listed are the Talairach coordinates, voxel number (size), and significance level for each region. p values denote significant differences in connectivity between APOE4+ and APOE4− groups.
↵*Significant at p ≤ 0.05 after Bonferroni correction for multiple comparisons.