Table 3.

Relationships between CSF biomarkers and morphometric ROIs in the MCI group

	t-tau		Aβ₄₂		p-tau		t-tau/Aβ₄₂		p-tau/Aβ₄₂
	F		F		F		F		F
	BL	Long	BL	Long	BL	Long	BL	Long	BL	Long
Subcortical ROIs
Cerebral white matter	1.51	1.0	1.72	0.94	1.38	0.74	1.04	0.09	0.70	0.01
Cerebellar white matter	1.22	4.69	0.64	0.02	1.23	6.35^*	0.98	3.34	0.93	4.90
Cerebellar gray matter	0.12	1.11	0.29	0.78	0.54	1.86	0.01	4.76	0.56	4.86
Thalamus	0.31	0.00	4.35	0.24	0.02	0.01	2.05	0.14	0.87	0.48
Caudate	15.58^*	0.77	1.80	0.05	15.68^*	0.28	10.84^*	0.06	10.59^*	0.00
Putamen	0.10	0.28	0.16	2.13	0.90	0.01	0.00	0.53	0.23	0.07
Pallidum	0.09	0.25	0.52	0.89	0.11	3.72	0.14	0.62	0.16	3.21
Hippocampus	2.45	7.31^*	2.85	7.08^*	2.21	7.00^*	2.54	5.14	2.01	5.51
Amygdala	2.05	14.50^*	2.68	14.20^*	1.81	23.91^*	2.06	11.58^*	1.49	20.03^*
Accumbens	1.11	2.19	1.41	1.32	1.25	2.20	0.57	1.23	0.65	1.11
Brainstem	0.06	2.93	0.23	0.89	0.05	2.54	0.01	5.27	0.04	4.04
Ventricular ROIs
Lateral ventricle	5.65	3.88	0.01	9.59^*	4.07	6.84^*	2.92	4.63	2.71	7.62^*
Inferior lateral ventricle	0.23	3.40	2.59	11.94^*	0.05	5.91	0.05	4.01	0.01	6.02
3rd ventricle	1.80	2.46	4.55	1.39	0.54	3.90	1.43	1.27	0.01	2.00
4th ventricle	0.89	0.74	0.05	1.99	0.68	0.91	0.30	1.96	0.20	1.99
Cortical ROIs
Cuneus	5.33	5.58	1.21	0.24	1.29	2.37	2.25	6.15	0.46	2.92
Entorhinal	6.99^*	9.25^*	3.80	11.85^*	6.49	18.03^*	6.82^*	4.64	5.98	11.66^*
Fusiform	3.85	3.98	1.32	18.27	2.18	8.51	3.34	2.57	1.71	6.34
Inferior parietal	5.37	2.42	0.58	8.94	2.96	7.70	3.82	0.54	1.96	4.01
Inferior temporal	8.23^*	7.12^*	0.75	11.76^*	3.12	13.75^*	5.55	3.28	1.88	7.65^*
Retrosplenial	2.91	3.66	0.41	3.25	2.98	3.40	2.22	0.71	1.90	1.00
Lateral orbfrontal	1.58	1.53	0.38	0.14	0.80	1.54	1.79	0.13	0.65	0.05
Lingual	0.26	0.35	0.01	5.43	0.77	0.00	0.02	0.05	0.60	0.02
Medial orbfrontal	0.11	3.98	0.05	0.83	0.00	3.50	0.16	3.35	0.00	2.56
Middle temporal	10.60^*	7.24^*	1.65	10.01^*	6.74^*	12.65^*	8.85^*	3.13	5.59	6.75^*
Parahippocampal	6.06	9.20^*	3.00	13.62^*	2.10	11.87^*	8.07^*	6.76^*	3.23	9.37^*
Precentral	0.44	2.11	2.71	0.24	0.02	0.50	0.03	3.82	0.10	1.80
Precuneus	8.64^*	0.09	0.39	4.59	6.51	1.28	5.49	0.08	4.05	0.40
Superior frontal	3.14	0.84	0.94	0.13	3.23	1.10	2.01	0.04	1.57	0.09
Supramarginal	4.10	0.71	0.00	2.59	1.80	1.74	3.15	0.02	1.21	0.17

BL, Baseline; Long, longitudinal.
↵*p < 0.01. Sex, age, and ICV were regressed out from all subcortical and ventricular variables, and sex and age were regressed out from all cortical variables, before they were entered into the analyses. Relationships at baseline are with volume (subcortical and ventricular ROIs) or thickness (cortical ROIs) and were tested by linear regression analyses. Relationships with longitudinal data are with percentage change for each ROI and were tested by mixed-effects general linear models.