Maximum interval likelihood fitting of the sequence of open and closed durations
| Rates | Experimental | Scheme I | ||
|---|---|---|---|---|
| Glycine | DCS | Glycine | DCS | |
| k1+ | 470 ± 85 | 420 ± 80 | ||
| k1− | 890 ± 265 | 1270 ± 340 | ||
| k2+ | 860 ± 160 | 1395 ± 215* | ||
| k2− | 15,630 ± 1700 | 17,510 ± 2135 | ||
| k3+ | 3735 ± 590 | 4795 ± 815 | ||
| k3− | 2630 ± 270 | 2150 ± 210* | ||
| k4+ | 60 ± 15 | 75 ± 35 | ||
| k4− | 1310 ± 225 | 1070 ± 130 | ||
| d1+ | 0.8 ± 0.3 | 1.2 ± 0.4 | ||
| d1− | 3.8 ± 1.0 | 4.2 ± 1.0 | ||
| d2+ | 17 ± 5 | 25 ± 8 | ||
| d2− | 33 ± 8 | 38 ± 7 | ||
| LL/event | 4.91 ± 0.03 | 4.86 ± 0.05 | ||
| Po | 0.019 | 0.028 | 0.018 | 0.029 |
| MOT | 0.46 | 0.57 | 0.46 | 0.61 |
↵Idealized current single-channel records were fitted to Scheme 1 as described in Figure 8. All rates have units of s−1. Data are mean ± SEM from six patches, each containing one active channel with a total of 11,275 and 16,662 open periods and 11,272 and 16,657 closed periods for glycine and DCS, respectively. The rates were compared by paired t test. *p < 0.05. MOT, mean open time.