Functional clusters of enriched GO categories (most significant category of each cluster shown)
| Annotation cluster # | Term | Category | Count | Genes | p value | Fold enrichment | Enrichment score |
|---|---|---|---|---|---|---|---|
| 1 | Transcription | GOTERM_BP_FAT | 29 | Per1, Ddit3, Egr2, Jun, Arid4b, Klf2, Nr4a3, Eid3, Ccnl1, Rax, Med14, Egr4, Txnip, Nr4a2, Nfil3, Fos, JunB, Npas4, Nr4a1, Btg2, Egr3, Zbtb10, Cry2, Gtf2a2, Crem, Stat1/Stat4, Atf3, FosB, Egr1 | 9.08E-09 | 3.49 | 7.0 |
| 2 | Positive regulation of macromolecule metabolic process | GOTERM_BP_FAT | 28 | Ddit3, Csrnp1, Klf4, Egr2, Zfp36, Rnf6, Jun, Irs2, F2, Klf2, Nr4a3, Hnrpll, Med14, Egr4, Barx2, Cdx1, Nr4a2, Rel, Gmpr2/Tinf, Klf4, Fos, JunB, Npas4, Nr4a1, Inhba, Gtf2a2, Pdgfb, Sertad1, Egr1 | 2.23E-06 | 2.74 | 5.9 |
| 3 | Basic-leucine zipper (bZIP) transcription factor | INTERPRO | 8 | Ddit3, Crem, Jun, FosB, Atf3, JunB, Fos, Nfil3 | 1.34E-06 | 13.89 | 5.1 |
| 4 | Regulation of apoptosis | GOTERM_BP_FAT | 21 | Sgk1, Txnip, Ddit3, Hipk1, Nr4a2, Rel, Jun, Rock1, Casp8ap2, Nr4a1, Btg2, Bdnf, Skil, Inhba, Dusp1, Hspb1, G2e3, Hspa1a/Hspa1l/Hspa1b, Ptgs2, Birc2, Stat1/Stat4 | 1.64E-04 | 2.56 | 3.7 |
| 5 | Membrane-enclosed lumen | GOTERM_CC_FAT | 27 | Klf4, Rnf6, Jun, Dld, Ptgs2, Ccnl1, Med14, Barx2, Txnip, Dusp6, Zbtb33, Hipk1, Dusp4, Rps6ka5, Rel, Midn, Gmpr2/Tinf, Klf4, Fos, Npas4, Nr4a1, Cdkn2aip, Gtf2a2, Pdgfb, Fxc1-ps1/Fxc1, Crem, Stat1/Stat4, Atf3 | 1.90E-04 | 2.13 | 3.3 |
| 6 | Negative regulation of cellular biosynthetic process | GOTERM_BP_FAT | 18 | Per1, Barx2, Txnip, Klf4, Dnajb5, Gmpr2/Tinf, Sik1, Klf4, Kdm6b, Insig1/LOC688922, Skil, Foxn3, Bcl6b, Zbtb10, Pdgfb, Pdcd4, Edn1, Egr1, Hbegf | 9.11E-05 | 3.00 | 2.9 |
| 7 | Response to oxidative stress | GOTERM_BP_FAT | 8 | Nd6, Txnip, Ddit3, Dusp1, Ptgs2, Jun, Stat1/Stat4, Fos | 6.38E-03 | 3.63 | 2.7 |
| 8 | Regulation of synaptic transmission | GOTERM_BP_FAT | 8 | Plk3, Bdnf, Plat, Arc, Egr2, Ptgs2, Edn1, Egr1 | 3.68E-03 | 4.02 | 2.6 |
| 9 | Transcription from RNA polymerase II promoter | GOTERM_BP_FAT | 7 | Med14, Ddit3, Gtf2a2, Jun, FosB, JunB, Fos | 1.10E-03 | 5.95 | 2.4 |
| 10 | Phosphate metabolic process | GOTERM_BP_FAT | 20 | Sgk1, Dusp6, Dusp4, Pim3, Gpd1, Rps6ka5, Alpk1, Sik1, Rock1, Fam63b, Dld, Bdnf, Plk3, Gadd45b, Gadd45g, Dusp1, Prkx, Lats1, Stat1/Stat4, Trib1 | 4.08E-03 | 2.02 | 2.2 |
| 11 | Blood vessel morphogenesis | GOTERM_BP_FAT | 8 | Gbx2, Plat, Cyr61, Tiparp, Jun, Edn1, JunB, Apold1 | 6.98E-03 | 3.57 | 1.8 |
| 12 | Negative regulation of protein kinase activity | GOTERM_BP_FAT | 6 | Dusp6, Gadd45g, Gadd45b, Hmgcr, Pdcd4, Trib1 | 1.64E-03 | 6.94 | 1.7 |
| 13 | Positive regulation of apoptosis | GOTERM_BP_FAT | 10 | Nr4a1, Txnip, Inhba, Ddit3, Dusp1, Hipk1, Ptgs2, Jun, Stat1/Stat4, Casp8ap2 | 1.91E-02 | 2.48 | 1.7 |
| 14 | Zinc finger, C2H2-type/integrase, DNA-binding | INTERPRO | 6 | Egr4, Egr3, Zbtb10, Egr2, Klf2, Egr1 | 4.49E-02 | 3.07 | 1.7 |
| 15 | Response to bacterium | GOTERM_BP_FAT | 7 | Defb10, Ptgs2, Jun, Stat1/Stat4, Fos, Pcsk1, Trib1 | 4.62E-02 | 2.67 | 1.6 |
| 16 | Response to progesterone stimulus | GOTERM_BP_FAT | 4 | Txnip, FosB, JunB, Fos | 6.56E-03 | 10.30 | 1.6 |
| 17 | ATPase activity, coupled to transmembrane movement of substances | GOTERM_MF_FAT | 5 | Abcc4, Atp11b, Atp13a3/LOC678704, Abcg2, Abcb1a | 3.19E-02 | 4.15 | 1.6 |
| 18 | Dual specificity protein phosphatase (MAP kinase phosphatase) | PIR_SUPERFAMILY | 3 | Dusp6, Dusp1, Dusp4 | 1.83E-03 | 42.71 | 1.4 |
| 19 | ABC transporters | KEGG_PATHWAY | 4 | Abcc4, Abcd2, Abcg2, Abcb1a | 8.77E-03 | 9.14 | 1.4 |
| 20 | Nerve growth factor IB-like nuclear receptor | PIR_SUPERFAMILY | 3 | Nr4a1, Nr4a2, Nr4a3 | 5.58E-04 | 71.18 | 1.3 |
| 21 | Sterol biosynthetic process | GOTERM_BP_FAT | 4 | Insig1/LOC688922, Idi1, Hmgcr, Ch25 h | 5.98E-03 | 10.64 | 1.3 |
| 22 | Negative regulation of apoptosis | GOTERM_BP_FAT | 9 | Btg2, Sgk1, Bdnf, Hspb1, Nr4a2, G2e3, Hspa1a/Hspa1l/Hspa1b, Birc2, Rock1 | 4.99E-02 | 2.21 | 1.3 |
| 23 | Nucleotide binding | GOTERM_MF_FAT | 34 | Htatsf1, Abcc4, Sgk1, Rap1b, Atp11b, Hmgcr, Abcg2, Rock1, Ddx50, Dld, Plk3, LOC306096, Hspa1a/Hspa1l/Hspa1b, Atp13a3/LOC678704, Lats1, Arl5b, Hnrpll, Abcb1a, Trib1, Pim3, Gpd1, Rps6ka5, Kif5b, Arl4d, Arl13b, Alpk1, Sik1, Mat2a, LOC499330, Prkx, Mat2a, Abcd2, Cry2, Rab18, Dync2h1 | 1.81E-02 | 1.47 | 1.3 |
Shown are the different functional clusters of significantly enriched GO categories of the differentially expressed genes. For each cluster, the term, category, count, and genes (Gene symbol) are shown, together with the p value and the fold enrichment.