Table 1.

Effects of substrates, inhibitors, and anti-oxidants on MPP+-disrupted mitochondrial axonal transport

Motile mitochondria (%)
Control18.41 ± 3.62
MPP+8.25 ± 1.34a
    + Glucose6.19 ± 1.26
    + Csp3I- II10.96 ± 2.58
    + Gö69766.16 ± 3.42
    + EGTA4.80 ± 2.70
    + SP6001254.63 ± 0.63
    + MnTBAP9.49 ± 1.51
    + NAC18.62 ± 3.53b
    + GSHEE15.49 ± 3.10b

  • Numbers are mean ± SEM.

  • ↵ap < 0.05 compared to control.

  • ↵bp < 0.05 compared to MPP+. Concentrations: MPP+, 2 μm; glucose, 20 mm; Csp3I-II (caspase-3 inhibitor II), 5 μm; Gö6976, 500 nm; EGTA, 2.5 mm; SP600125, 10 μm; MnTBAP, 100 μm; NAC (N-acetylcysteine),2.5 mm; GSHEE, 5 mm.