GABAA receptor subunit (gene) | Expression relative to β-actin in α2fl/fl mice (mean ± SEM) | Expression ratio (sns-α2−/−/α2fl/fl) (mean ± SEM) | P |
---|---|---|---|
α4 (Gabra4) | 7.6 ± 0.34×10−5 | 1.45 ± 0.25 | 0.004 |
α6 (Gabra6) | n.d. | ||
δ (Gabrd) | 2.9 ± 0.45×10−4 | 1.41 ± 0.45 | n.s. |
ϵ (Gabre) | 2.2 ± 0.21×10−4 | 1.10 ± 0.26 | n.s. |
π (Gabrp) | n.d. | ||
θ (Gabrq) | 2.5 ± 0.41×10−4 | 1.37 ± 0.29 | n.s. |
ρ1 (Gabrr1) | 2.6 ± 0.39×10−4 | 1.23 ± 0.14 | n.s. |
ρ2 (Gabrr2) | n.d. | ||
ρ3 (Gabrr3) | 1.8 ± 0.33×10−4 | 0.90 ± 0.11 | n.s. |
Gene expression for both genotypes was first calculated relative to β-actin expression, and then compared between sns-α2−/− and α2fl/fl mice. n.d., Not detectable. α6 transcripts were not detectable in any of the samples, and transcripts for π and ρ2 were only found in two out of 16 samples. P, Significance calculated by ANOVA followed by Bonferroni correction for six independent samples. n.s., Not significant after Bonferroni correction. Number of mice, n = 8 and 7, for α2fl/fl and sns-α2−/−, respectively.