Representative genes that are downregulated in Dicer mutant and enriched in mature astrocytes
| Gene symbol | Gene title | Biological pathway | Downregulation fold in Dicer Mutant CB | FDR | Enrichment fold (mature over immature astrocytes) |
|---|---|---|---|---|---|
| Cyp2d22 | Cytochrome P450, family 2, subfamily d, polypeptide 22 | Oxidation reduction | 1.547 | 0.0007 | 5.5 |
| Cyp4f14 | Cytochrome P450, family 4, subfamily f, polypeptide 14 | Oxidation reduction | 1.525 | 0.0003 | 2.7 |
| Cyp4v3 | Cytochrome P450, family 4, subfamily v, polypeptide 3 | Oxidation reduction | 1.362 | 0.0207 | 2 |
| Cyp2j9 | Cytochrome P450, family 2, subfamily j, polypeptide 9 | Oxidation reduction | 1.547 | 0 | 1.8 |
| Maob | Monoamine oxidase B | Oxidation reduction | 1.851 | 0 | 3.8 |
| Ptgs1 | Prostaglandin-endoperoxide synthase 1 | Oxidation reduction | 1.504 | 0.0006 | 3.8 |
| Gpd1 | Glycerol-3-phosphate dehydrogenase 1 (soluble) | Oxidation reduction | 1.334 | 0.0008 | 3.3 |
| Dio2 | Deiodinase, iodothyronine, type II | Oxidation reduction | 1.867 | 0 | 2.6 |
| BC055107 | Family with sequence similarity 107, member A | Regulation of cell growth, nuclear factor | 2.557 | 0 | 14.4 |
| Id4 | Inhibitor of DNA binding 4 | Transcription repressor | 1.802 | 0 | 2.4 |
| Lgi4 | Leucine-rich repeat LGI family, member 4 | Cellular homeostasis | 2.327 | 0 | 3.1 |
| Mt1 | Metallothionein 1 | Cellular homeostasis | 1.444 | 0 | 2.2 |
| Mt2 | Metallothionein 2 | cellular homeostasis | 1.478 | 0 | 1.8 |
| S100b | S100 protein, β polypeptide, neural | Cellular homeostasis | 1.474 | 0 | 3.5 |
| Ntsr2 | Neurotensin receptor 2 | Cellular homeostasis | 2.031 | 0 | 2.3 |
| S100a | S100 calcium binding protein A1 | Calcium binding | 1.598 | 0 | 1.6 |
| Fxyd1 | FXYD domain-containing ion transport regulator 1 | Calcium ion homeostasis | 1.46 | 0 | 2.6 |
| Slc1a2 (GLT-1) | Solute carrier family 1 (glial high-affinity glutamate transporter), member 2 | Glutamate transport | 1.509 | 0 | 2.2 |
| Gabrg1 | GABAA receptor, subunit γ-1; similar to GABAA receptor subunit α-2 | Chloride transport, GABA signaling | 1.701 | 0 | 1.6 |
| Gpc5 | Glypican 5 | Extracellular matrix, heparan sulfate proteoglycan binding | 1.602 | 0.0022 | 2.4 |
| Gstm1 | Glutathione S-transferase, μ1 | Glutathione transferase | 1.552 | 0 | 1.6 |
| Gstm5 | Glutathione S-transferase, μ5 | Glutathione transferase | 1.279 | 0.0156 | 1.8 |
| Clu | Clusterin | Anti-apoptosis | 1.707 | 0 | 1.7 |