Representative genes that are upregulated in Dicer mutant and enriched in immature astrocytes
| Gene symbol | Gene title | Biological pathway | Upregulation fold in Dicer mutant CB | FDR | Enrichment fold (immature over mature astrocytes) |
|---|---|---|---|---|---|
| Vim | Vimentin | Intermediate filament-based process | 1.895 | 0 | 3.4 |
| Dcx | Doublecortin | Axon extension, cell differentiation | 1.557 | 0.0004 | 2.8 |
| Nedd9 | Neural precursor cell expressed, developmentally downregulated gene 9 | Cell cycle, cell adhesion | 1.423 | 0.0287 | 2.1 |
| Nes | Nestin | Positive regulation of neural precursor cell proliferation | 1.511 | 0.0013 | 3.6 |
| Frem2 | Fras1-related extracellular matrix protein 2 | Cell adhesion | 5.937 | 0 | 12.9 |
| Melk | Maternal embryonic leucine zipper kinase | Cell cycle | 2.28 | 0.0227 | 9.5 |
| Cdc2a | Cyclin-dependent kinase 1 | Cell cycle | 2.4 | 0 | 12.9 |
| Mki67 | Antigen identified by monoclonal antibody Ki 67 | Cell cycle | 1.837 | 0.0011 | 10.9 |
| Ccna2 | Cyclin A2 | Cell cycle | 1.387 | 0.0435 | 7.5 |
| Cenpf | Centromere protein F | Cell cycle | 1.975 | 0 | 6 |
| Cdca3 | Cell division cycle-associated 3 | Cell cycle | 1.709 | 0.0001 | 4 |
| Ccnb1 | Predicted gene 8416; predicted gene 5593; cyclin B1; similar to cyclin B1; predicted gene 4870 | Cell cycle | 2.494 | 0.0401 | 3.9 |
| Ccnd2 | Cyclin D2 | Cell cycle | 2.039 | 0 | 2.2 |
| Ccnd1 | Cyclin D1 | Cell cycle | 2.016 | 0 | 1.9 |
| Birc5 | Baculoviral IAP repeat-containing 5 | Cell cycle, apoptosis | 1.804 | 0 | 6.5 |
| Ckap2 | Cytoskeleton-associated protein 2 | Cell cycle, apoptosis | 2.133 | 0 | 4.1 |
| Dtl | Denticleless homolog (Drosophila) | Regulation of cell cycle | 2.253 | 0.0007 | 4.3 |
| Hmgb2 | High mobility group box 2 | Nervous system development | 1.575 | 0 | 3.2 |
| Dpysl3 | Dihydropyrimidinase-like 3 | Nervous system development | 1.381 | 0.0015 | 3.1 |
| Adam17 | A disintegrin and metallopeptidase domain 17 | Notch signaling pathway, cell adhesion | 1.427 | 0.014 | 1.6 |
| Cybrd1 | Cytochrome b reductase 1 | Oxidation reduction | 4.758 | 0 | 3 |
| Plod2 | Procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 | Oxidation reduction | 3.531 | 0 | 2.4 |
| Loxl1 | Lysyl oxidase-like 1 | Oxidation reduction | 1.895 | 0 | 2.8 |
| Egln3 | EGL nine homolog 3 (C. elegans) | Oxidation reduction, apoptosis | 1.677 | 0.0001 | 2.6 |