Parameter | Control antibody | β1 antibody | Statistics |
---|---|---|---|
Blood vessels with CAA | 25.6 ± 3.8 | 33.9 ± 3.3 | p = 0.04 |
Areas with iron containing macrophages (total) | 3.6 ± 1.2 | 15.2 ± 3.0 | p = 0.03 |
By severity grade | |||
Low: 1–3 macrophages | 0.9 ± 0.6 | 7.1 ± 1.6 | p = 0.006 |
Moderate: 4–10 macrophages | 2.5 ± 0.9 | 6.7 ± 1.3 | p = 0.01 |
Abundant: >10 macrophages | 0.3 ± 0.2 | 1.4 ± 0.5 | n.s. |
Amyloid vessels with iron-containing macrophages | 2.6 ± 0.7 | 3.0 ± 0.5 | n.s. |
Numbers (means ± SEM) refer to counts of areas in the vicinity of CAA vessels presenting iron-containing macrophages, averaged over 11 sections per animal.