Table 1.

Passive and active parameters

	Unit	WT (no. of cells = 18)		SCA1 (no. of cells = 38)		t test
	Unit	Mean	SEM	Mean	SEM	t test
Passive parameters
Access resistance	MΩ	23.65	1.11	22.86	2.85	0.89	NS
Apparent membrane capacitance	pF	334.14	25.17	349.32	18.74	0.63	NS
Membrane input resistance	GΩ	0.14	0.02	0.16	0.02	0.56	NS
Resting membrane potential	mV	−58.55	1.36	−57.39	1.00	0.51	NS
Action potential analysis (injected current = 0 pA)
Afterhyperpolarization	mV	−63.38	1.09	−61.54	0.95	0.25	NS
Frequency	Hz	42.27	3.22	29.11	2.06	0.00	^**
Half-width	ms	0.27	0.01	0.25	0.01	0.17	NS
Ascending slope	V/s	314.31	32.70	361.00	17.02	0.17	NS
Descending slope	V/s	−226.84	27.57	−235.53	12.79	0.74	NS
Action potential analysis (excitability recordings)
Afterhyperpolarization	mV	−68.18	1.53	−65.40	0.95	0.13	NS
Half-width	ms	0.23	0.01	0.22	0.01	0.49	NS
Ascending slope	V/s	368.52	26.60	420.36	16.06	0.10	NS
Descending slope	V/s	−277.09	25.77	−293.49	14.98	0.56	NS
Excitability slope	Hz/pA	0.23	0.02	0.21	0.01	0.13	NS

Passive parameters and action potential analysis from patch-clamp recordings of Purkinje cells from 2- to 3-week-old WT and SCA1 mice.
↵NS, No significant difference (p > 0.05); **p < 0.01.