Properties of continuous theta–gamma oscillations recorded in the Cg and PL of prejuvenile rats under control conditions (intracortical application of ACSF), after blockade of mAChRs or nAChRs with intracortically applied atropine or MLA, and after activation of nAChRs with intracortically applied nicotine
| Properties | Continuous activity (P14–P15) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cg | PL | |||||||||||
| ACSF | Atropine | ACSF | Nicotine | ACSF | MLA | ACSF | Atropine | ACSF | Nicotine | ACSF | MLA | |
| Amplitude (μV) | 146.38 ± 3.59 | 348.7 ± 20.67 | 229.36 ± 8.38 | 204.18 ± 6.88 | 261 ± 8.72 | 247.82 ± 8.03 | 216.62 ± 4.23 | 262.68 ± 8.9 | 244.66 ± 7.96 | 225.14 ± 6.16 | 277.83 ± 9.31 | 251.83 ± 6.14 |
| (p = 4E-13)*** | (p = 2E-6)*** | (p = 2E-5)*** | (p = 0.036)* | (p = 0.0004)*** | ||||||||
| Main frequency (Hz) | 7.02 ± 0.14 | 6.84 ± 0.12 | 5.74 ± 0.11 | 5.92 ± 0.1 | 6.17 ± 0.14 | 6.02 ± 0.1 | 6.55 ± 0.13 | 6.32 ± 0.13 | 5.97 ± 0.1 | 5.88 ± 0.09 | 5.95 ± 0.14 | 6.06 ± 0.13 |
| Relative power theta (%) | 31.43 ± 0.55 | 39.02 ± 1.15 | 43.55 ± 0.5 | 41.11 ± 0.43 | 42.49 ± 0.42 | 42.89 ± 0.37 | 38.67 ± 0.49 | 40.61 ± 0.61 | 44.1 ± 0.69 | 40.72 ± 0.63 | 40.43 ± 0.4 | 41.6 ± 0.43 |
| (p = 1E-18)*** | (p = 0.004)** | (p = 0.001)* | (p = 7E-7)*** | (p = 0.011)* | ||||||||
| Relative power alpha (%) | 27.15 ± 0.4 | 28.74 ± 0.51 | 24.17 ± 0.25 | 23.89 ± 0.3 | 27.32 ± 0.36 | 26.81 ± 0.34 | 26.83 ± 0.32 | 26.75 ± 0.39 | 23.98 ± 0.26 | 24.14 ± 0.29 | 26.85 ± 0.42 | 26.17 ± 0.41 |
| (p = 0.015)* | ||||||||||||
| Relative power beta (%) | 23.82 ± 0.47 | 19.78 ± 0.82 | 17.45 ± 0.42 | 20.53 ± 0.54 | 15.83 ± 0.32 | 16.06 ± 0.3 | 19.09 ± 0.37 | 18.96 ± 0.57 | 18.07 ± 0.53 | 21.72 ± 0.77 | 17.2 ± 0.37 | 16.92 ± 0.41 |
| (p = 1E-5)*** | (p = 1E-7)*** | (p = 3E-9)*** | ||||||||||
| Relative Power gamma (%) | 14.31 ± 0.41 | 9.25 ± 0.64 | 5.71 ± 0.17 | 6.13 ± 0.15 | 5.21 ± 0.17 | 5.7 ± 0.21 | 9.81 ± 0.32 | 8.45 ± 0.36 | 5.8 ± 0.23 | 6.08 ± 0.18 | 6.72 ± 0.26 | 6.71 ± 0.29 |
| (p = 2E-8)*** | (p = 0.0002)*** | (p = 2E-6)*** | (p = 0.029)* | |||||||||
| Main frequency in gamma band (Hz) | 38.79 ± 0.56 | 38.4 ± 0.44 | 35.36 ± 0.4 | 34.75 ± 0.31 | 37.51 ± 0.47 | 37.21 ± 0.41 | 37.74 ± 0.53 | 37.73 ± 0.44 | 35.22 ± 0.4 | 35.99 ± 0.46 | 37.17 ± 0.42 | 37.05 ± 0.34 |
↵Values are presented as mean ± SEM, and significance values (*p < 0.05, **p < 0.01, ***p < 0.001, Mann–Whitney–Wilcoxon test) are indicated in parentheses.