Table 3.

Categorization of transplanted ESNP-derived neurons based on electrophysiological properties

ParameterType I (10)Type II (4)Type III (11)Type IV (4)Type V (1)GIN (5)p < 0.05
Membrane potential (mV)−48.50 ± 2.4−52.3 ± 3.1−49.4 ± 2.5−58.0 ± 2.7−68−44.7 ± 2.6
Delay to spike (ms)19.7 ± 4.215.2 ± 6.118.0 ± 3.912.7 ± 4.344.216.6 ± 4.2
Spike threshold (mV)−38.7 ± 1.7−39.0 ± 4.0−40.8 ± 2.3−40.8 ± 4.3−22.5−41.8 ± 1.2
AP amplitude (mV)67.1 ± 2.929 ± 2.663 ± 3.962 ± 6.231.359.5 ± 6.0I–II,
II–III,
II–IV, II–GIN
AP half-width (ms)0.82 ± 0.061.13 ± 0.431.04 ± 0.10.78 ± 0.092.10.96 ± 0.1
AP drop (mV)6.0 ± 1.4−2.3 ± 0.47.1 ± 1.63.2 ± 1.44.50.8 ± 1.2I–II,
II–III
Maximum frequency (Hz)46.5 ± 3.250.7 ± 12.350.4 ± 8.155.2 ± 8.718.469.9 ± 17.6
Maximum number of APs19.4 ± 2.424.5 ± 6.09.5 ± 1.025.8 ± 5.0820.3 ± 6.7I–III,
II–III,
III–IV
Adaptation2.0 ± 0.22.2–0.32.3 ± 0.32.1 ± 0.22.31.6 ± 0.3
AHP1 amplitude (mV)−18.1 ± 2.6−7.9 ± 1.6−15.0 ± 2.0−16.6 ± 1.9−9.3−11.6 ± 1.8
AHP2 amplitude (mV)−4.1 ± 0.9−6.1 ± 2.3−0.7 ± 0.7−3.3 ± 1.20−1.6 ± 1.6II–III
Voltage sag ratio1.47 ± 0.081.63 ± 0.261.01 ± 0.011.03 ± 0.0311.17 ± 0.07I–IV,
I–III,
II–III,
II–IV, II–GIN
Input resistance (MΩ)717 ± 98450 ± 51784 ± 107641 ± 92377529 ± 83