Drug effects on APP processing and Notch signaling in cells
| LY450139 (nm) | BMS-708163 (nm) | GSM-2 (nm) | |
|---|---|---|---|
| Aβ42 | |||
| IC50 | 10.9 ± 0.6 | 0.79 ± 0.15 | 65.2 ± 2.3 |
| Aβ40 | |||
| IC50 | 12.1 ± 0.5 | 0.78 ± 0.09 | >2000 |
| Aβ38 | |||
| IC50 | 12.0 ± 0.3 | 0.66 ± 0.02 | — |
| EC50 | — | — | 81.3 ± 6.0 |
| β-CTF | |||
| ECmaxa | 16.0 ± 0.0 | 0.80 ± 0.00 | No change |
| Notch | |||
| IC50 | 14.1 ± 2.5 | 20.6 ± 1.3 | >3000 |
| Notch/Aβ42 | 1.3 | 26 | >46 |
Values are shown as mean ± SEM for three independent experiments.
↵aConcentration at which maximum increases in β-CTF were observed.