Diagnosis, age, and postmortem delay of human brain tissues used
| Diagnosis | Age (years) | PMD (h) | |
|---|---|---|---|
| Controls without BrSt LBDs | Control | 66 | 10 |
| Control | 74 | 4 | |
| AD | 78 | 4 | |
| AD | 88 | 14 | |
| AD | 80 | 9 | |
| AD | 92 | 7 | |
| AD | 78 | 8 | |
| AD | 69 | 10.5 | |
| PD with BrSt LBDs | PD w/dementia | 75 | 9 |
| PD w/dementia | 83 | 5 | |
| PD w/dementia/AD | 80 | 16 | |
| PD/AD probable | 82 | 5 | |
| PD/AD possible | 75 | 9 | |
| PD/AD possible | 85 | 14 | |
| PD/diffuse Aβ deposits | 77 | 16 | |
| PD/LBD | 90 | 16 | |
| PD/AD/LBD | 84 | 12 | |
| PD/AD | 64 | 21 | |
| PD | 85 | 14 | |
| PD | 76 | 18 |
All PD cases exhibit brainstem (BrSt) α-synuclein pathology level of at least 10 where as the controls are 2 or less (Pletnikova et al., 2005). AD, Alzheimer's disease; LBD, Lewy body dementia; MID, mutiple infarct dementia; PD, Parkinson's disease; PMD, postmortem delay.