Structural analysis, comparison of grey matter integrity
| Left hemisphere brain regions | Controls > severe patients | Controls > moderate patients Z score (coordinates) | Moderate patients > severe patients Z score (coordinates) | |||
|---|---|---|---|---|---|---|
| Coordinates | Z score | |||||
| x | Y | z | ||||
| Grey matter VBM | ||||||
| Supratemporal plane (anterior to posterior) | ||||||
| 1. Planum polare | −46 | 8 | −2 | 6.1 | 5.4 (−48 8 −2) | ns |
| 2. Anterolateral Heschl's gyrus (A1) | −56 | −12 | 6 | 7.6 | ns | 4.3 (−58 −12 2) |
| 3. Planum temporale | −66 | −28 | 2 | 7.1 | ns | 4.3 (−62 −26 2) |
| 4. Posterior superior temporal sulcus | −60 | −54 | 14 | 7.8 | ns | ns |
| Insula cortex | ||||||
| Long (posterior) insula gyrus | −38 | −10 | 2 | 7.3 | 5.6 (−40 −8 2) | 5.6 (−34 −14 −2) |
| Inferior frontal gyrus | −54 | 12 | 14 | 5.5 | ns | ns |
| Pars opercularis | ||||||
| Subcortical | ||||||
| Putamen | −22 | 2 | 2 | 6.6 | 5.8 (−20 6 2) | ns |
| Caudate (body) | −14 | −16 | 16 | 6.6 | 6.5 (−14 −16 16) | ns |
| White matter VBM | ||||||
| Arcuate fasciculus | ||||||
| 1. Parietal portion | −34 | −40 | 24 | Inf | 7.4 (−28 −42 20) | 5.0 (−34 −38 24) |
| 2. Temporal portion | −36 | −32 | −6 | 14.6 | 7.5 (−34 −32 −6) | 4.4 (−40 −36 4) |
| 3. Frontal portion | −42 | −2 | 24 | 6.3 | 6.4 (−18 −6 28) | ns |
| Intrinsic temporal lobe white matter | −50 | −20 | −2 | 7.3 | ns | 4.3 (−52 −16 −2) |
Coordinates are in MNI space. The location and extent of these regions are illustrated in Figure 2, where numbers 1–4 relate to the key regions in the supratemporal plane for gray matter, and 1–3 relate to different parts of the arcuate fasciculus for white matter.