Table 2.

The neural correlates of the return of consciousness during constant level dexmedetomidine revealed by PLS

Brain regionsBrodmann areaMNI coordinates (in mm) x, y,zCluster size (voxels)BSRp value
Latent Variable 1
    Positive salience—shown in Figure 2
        L superior frontal gyrus8/9/10/11−20, 62, 2079317.26<0.0001
        R anterior prefrontal10/1136, 62, −2483416.0008<0.0001
        Cerebellum0, −78, −42810215.2835<0.0001
        Superior frontal gyrus8/9/10/1114, 70, 2623113.6909<0.0001
        Thalamus10/24−4, −14, 14142910.2229<0.0001
        R superior temporal sulcus3968, −68, 2221910.0856<0.0001
        L inferior frontal gyrus13/46/47−36, 16, −1685010.0765<0.0001
        R inferior parietal39/4056, −68, 505388.8778<0.0001
        R medial frontal gyrus8/96, 36, 3412047.9879<0.0001
        L superior temporal gyrus38−36, 14, −661127.4662<0.0001
        R middle frontal gyrus6/8/940, 28, 441217.2273<0.0001
        Brainstem/pons8, −36, −328367.1674<0.0001
        R middle frontal gyrus6/8/932, 62, 241556.7936<0.0001
        R inferior frontal gyrus13/46/4744, 34, −146456.611<0.0001
        L inferior parietal39/40−54, −62, 381836.5215<0.0001
        L orbital gyrus11−14, 56, −568906.5092<0.0001
        Anterior cingulate24/32−14, 48, −62396.2658<0.0001
        R orbital gyrus1116, 58, −662195.8429<0.0001
        L inferior frontal gyrus13/46/47−30, 38, −321155.6669<0.0001
        L supramarginal gyrus40−72, −52, 281155.6521<0.0001
    Negative salience
        L parahippocampal gyrus20/35/36−30, −36, −166488−22.0599<0.0001
        R lingual gyrus17/1918, −44, −69395−18.9551<0.0001
        R angular gyrus3934, −62, 362176−18.1224<0.0001
        L inferior parietal39/40−36, −42, 422122−14.0804<0.0001
        R middle frontal gyrus6/8/946, 4, 401674−13.5639<0.0001
        L postcentral gyrus2/3/4−12, −40, 681306−6.3560<0.0001
        L lingual gyrus17/19−12, −92, −2143−4.3952<0.0001

  • Corresponding clusters are shown in Figure 2. MNI, Montreal Neurological Institute; BSR, Bootstrap ratio.